Pharmacology Practical Essay Example | Topics and Well Written Essays - 500 words

Pharmacology Practical - Essay Example The experiment provided a uniform temperature (37 degrees) for the enzyme activity, whereas in living systems the temperature usually varies within a given range. According to Yun, crude extracts of orlistat also contain an inactive component, which is a possibility in the in vivo action of orlistat that leads to the disparities between experimental values and theoretical values of IC50 (2010). The suggested dose of Orlistat is one 120 mg capsule immediately before, during or up to one hour after, each main meal. From the statement, In general, at therapeutic doses detection of intact Orlistat in plasma is sporadic and concentrations are extremely low ( Orlistat’s systemic absorption is minimal because most of it is largely maintained in the gastrointestinal tract. This is why extremely low plasma concentrations are observed after the intake of the drug (Bryant et al. 2011). Systemic absorption of Orlistat is not necessary for its activity because it provides its therapeutic action in the stomach lumen and ileum. Orlistat binds irreversibly to the amino acid residues serine present in the active sites of gastric and pancreatic lipases through the formation of covalent bonds. This binding inactivates the enzymes making them unavailable for the hydrolysis of dietary fat (triglycerides) into fatty acids and monoglycerides (Orlistat STADAÂ ® 60mg/120 mg 2011). Consequently, a caloric deficit ensues because of failure of absorption of the undigested triglycerides. The caloric deficit has a helpful outcome on the regulation of

Comparing Different Linux Vendors Research Paper

Comparing Different Linux Vendors - Research Paper Example It is based on Unix. Linux was developed in collaboration with many different companies, thus, all these companies are responsible for its development. The development and research costs are shared amongst the partners and other competitors. As many companies are involved, there is lot of innovation in this operating system. Here we will discuss three major distributors of Linux, namely: Ubuntu, Fedora and Linux Mint. It is also important to understand their advantages and disadvantages in servers and workstations. Ubuntu Server and Workstations – Installation of Ubuntu is easy which is beneficial for business. Its foundations are built on the bases of Debian. This server is fast and delivers high performance, which makes it highly reliable. It is composed of many new server based applications like â€Å"LAMP, file server, firewall and thin client support† â€Å"With LAMP it is easy to setup a web server, database applications and dynamics websites.† â€Å"It in cludes the use of thin clients using LTSP (linux terminal server project). Thus saving the cost on expensive hardware to keep up to date with the ever growing pc demands† (Ubuntu Server, 1998, para.4). Ubuntu is free. Strong firewalls prevent the server from any attacks, thus making it secure. It provides high security. It has a â€Å"bunch of applications like Open Office, alternative to Microsoft Office, web browsers, email clients, games, audio & movie players, image editors and many more† (Ubuntu Workstation, 1998, para.2). Applications can be downloaded free of cost. It is stable and there are rarely any errors or system crashes. It is a secure operating system as there are no viruses or any other applications that could harm the computer. Ubuntu is not easy to use. It has an online community, which offers support and provides updates for the improvement of the system. Updates of Ubuntu are available every six months. Ubuntu’s approach towards new technologi es is conservative, unlike Fedora, which rather supports new technologies. Ubuntu is found to have hardware complaints, which makes it less stable than Fedora. It requires a reasonable space to work efficiently as it is large. Fedora Server and Workstations – Fedora is an open source and, therefore, it can be downloaded, installed and shared for free. It has a wide range of free applications available. Free from virus, thus, no hassles with antivirus software and spywares. A powerful operating system, which is both efficient and secure. Consists of new features making it more flexible and stable. It is reliable as any kind of hardware failures are efficiently handled without affecting the entire operating system. Help docs are provided and there are communities that provide assistance when needed. Updates are released twice in a year, so no long wait is required to achieve latest software. Frequent updates are also a drawback as it makes it look less stable. It may be a good choice but a new user may find it hard to use. â€Å"Ruby,Python,Database Server: MySQL 5.0.67,Mail Server: Postfix ,DNS Server: BIND9 (chrooted) ,FTP Server: proftpd,POP3/IMAP server: Dovecot,Webalizer for web site† (Timme, 2012, para.2). If some issue arises, the user has to resort to the command line in order to complete the task In case of software updates with two packages, it is difficult to trace the unwanted package. There is a